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However, so far, there is a lack of longitudinal studies illustrating whether poor vascularization and low-level expression of VEGF are the cause of poor healing or merely the sign of poor healing in degenerative tendons ( We cannot deny the importance of early neovascularization for nutrition at the injury site, and therefore, we can identify VEGF-mediated ECM degradation as a negative side-effect accompanied by neovascularization during the remodeling phase ( When a tendon lesion is fully healed, newly formed blood vessels usually regress, and the prolonged presence of blood vessels is thought to result in an adverse healing microenvironment

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Article Google Scholar Jackson, L

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