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doi: 10.1016/j.pbiomolbio.2017.07.011 132 SungH.FerlayJ.SiegelR

The patient lacks intrinsic factor, a protein mandatory for the intestinal uptake of a physiological dose of B12

The fourth option is exemplified by the use of the streptococcal endopeptidase imflimidase, which cleaves the HC of all four subclasses of IgG and the IgG-like B cell receptor on CD19 + memory B cells [410,411,412], thereby depleting the IgG pool and possibly lowering the production of IgG [410, 413]