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113 At present, glucocorticoids, immunosuppressants, and biological agents are the primary treatment methods for RA

Sa prsence est particulirement abondante dans certains tissus, notamment le foie, les reins et les poumons, ce qui tmoigne de son importance fonctionnelle dans des organes exposs un fort stress mtabolique

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Heart failure itself can also cause sterile inflammation, with cardiomyocytes and cardiac fibroblasts releasing pro-inflammatory cytokines (such as TNF-, IL-6, IL-1) when subjected to mechanical stretching and increased wall tension, activating the NLRP3 inflammasome and further exacerbating inflammation (268)