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In the context of low or often undetectable neutralizing activity of antibodies, the fact that vaccine- or previous SARS-CoV-2-induced immunity can retain its ability to limit viral replication and to clear infection indicates the important protective roles of non-nAbs and T cells

Binding sites have been found in many areas of the brain, including the pars tuberalis and hypothalamus, but also in the cells of the immune system, gonads, kidney, and the cardiovascular system (39, 40)

No human clinical trial has validated this schedule, route, or dose

Phytoestrogens from Siberian rhubarb have been shown to preferentially activate ER-beta, with a significantly weaker effect on ER-alpha, indicating its probable safety in breast and endometrial tissues