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308 Historically, a natural menopausal transition has been recognized as a life stage marked by gradually decreasing levels of estradiol (E2, the predominant ovarian estrogen) and progesterone accompanied by increasing levels of FSH and LH, beginning in earnest about two years before and stabilizing about two years after the last menstrual period

Preclinical findings do not predict human outcomes, and no safety or efficacy claims are made

Cyanocobalamin can be converted to 5-deoxyadenosylcobalamin and methylcobalamin in the body