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Proteasome inhibition results in stabilization of several key tumor suppressing proteins (e.g., NFKB inhibitor alpha [NFKBIA/IKBA] (Li and Dou, 2000), cyclin-dependent kinase inhibitor 1A [CDKN1A/p21] (Pagano et al., 1995), and tumor protein p53 [TP53] (Lopes et al., 1997)), which are responsible for cell growth inhibition or cell death induction

Recently studies on Fe-S cluster biosynthesis in the important eukaryotic pathogen Toxoplasma gondii , have revealed the presence and functional importance of components from the ISC pathway in mitochondria (21, 23), the SUF pathway in the apicoplast (21, 22) and the cytosolic pathway (23)

On the other hand, the same dose of 20 mg can be tried for 72 hrs or higher for 1- 3 times a week application

The 12mg dose represents the optimal balance point identified in clinical trials