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Description

Dihydrofolate reductase deficiency is an autosomal recessive disorder caused by homozygous mutation in the DHFR gene on chromosome 5q

Gene ontology analysis of the gene set from cluster 1 revealed a significant enrichment of gene ontology terms associated with critical cellular processes, including dopaminergic synaptic transmission, prepulse inhibition and enriched biological processes (like locomotor behaviour and drug response) (Extended Data Fig