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In adults, BMP9 is synthesized in the liver by hepatic stellate cells, while BMP10 is primarily synthesized in the right atrium, with lower expression also detected in the liver 25

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Journal of Investigative Dermatology , 142(5), 12731282

The Boxed Warning was revised to include the presence of the HLA-B*15:02 allele as a risk factor for developing Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) in patients using lamotrigine