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These antigens would eventually be recognized by B and T cells, triggering creation of a proinflammatory environment with release of cytokines and activation of fibroblasts along with increased production of collagen.62 TGF- also appears to play an important role.62 The induration may improve spontaneously but, like idiopathic morphea, the radiation-induced form presents therapeutic challenges

The primers used for validation are listed in Table S2

Depletion of CAFs from the culture system reduced the expression of stemness markers OCT4/SOX2/NANOG and the anchor-independent capacity in CSCs, whereas it increased the expression of differentiation markers such as adenocarcinoma and squamous carcinoma markers (thyroid transcription factor 1, CK7, CK20, p63, and keratin 5/6)

Endogenous cardiotonic steroids and salt-sensitive hypertension