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These genes included CP (Matsuoka et al., 2018), Cu transporter 2 ( CTR2 ) ( ATOX1 ( CCS ) (Hu et al., 2023), Cu chaperone for cytochrome c oxidase ( COX ) 11 ( COX17 (Suzuki et al., 2003), synthesis of cytochrome oxidase ( SCO ) 1 (Zhang et al., 2021), SCO2 (Liu et al., 2018), cytochrome c oxidase assembly factor 6 ( COA6 ) (Zhang et al., 2023), solute carrier family 25 member 3 ( SLC25A3 ), MT1 and MT2 (Sauler et al., 2022), subunits 1 and 2 of cytochrome c oxidase ( COX1 and MT-CO2 ), SOD1 (Skrska et al., 2021

By month nine, the curve had begun to flatten

164 It was proved that Temporin-1CEa could co-localize with P-gP on the surface of drug-resistant cell membranes, so the anticancer mechanism of Temporin-1CEa may be acting on P-gP and affecting its efflux function, thereby reversing multidrug resistance in tumor cells

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