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Direct HGH overrides that pulse and can suppress your own endogenous production over time

2- Timing & split dosing: Because Ipamorelin induces pulsatile GH, many protocols favor pre-bed, pre-workout, or split dosing (morning + evening) to mirror natural GH rhythms

While there are numerous GHRPs in existence, Ipamorelin is the only one that SELECTIVELY releases growth hormone: Very surprisingly, ipamorelin did not release ACTH or cortisol in levels significantly different from those observed following GHRH stimulation