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76 found that Rb1-inducible coiled-coil 1-induced upregulation of coiled-coil helix coiled-coil helix domain-containing protein 3 expression to stimulate mitochondrial function and increase ROS production, resulting in increased sensitivity of HCC cells to ferroptosis, and suggesting that Rb1-inducible coiled-coil 1 is a promising target for ferroptosis-based antitumor therapy