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Mutations in IDH1 and IDH2 elevate 2HG levels, inducing hypermethylation at H3K9 and H3K27, thereby blocking histone demethylation and promoting oncogenic epigenetic alterations (138)

Therefore, we hypothesize that in the preeclamptic placenta the high fatty acid concentrations can be responsible for metabolic reprogramming as in the case of tumor cells, resulting in insufficient fatty acid availability for CD8 + T cells and inhibited CD8 + T cell function