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As discussed, improvements in TTE with RR supplementation in murine models have been associated with higher resting liver glycogen content and attenuated exercise-induced reductions in muscle glycogen (Reference Lee, Kuo and Liou12) , suggesting that alterations in glycogen turnover potentially contribute to ergogenic effects on endurance exercise following chronic supplementation

2 Mapping cerebellar circuits: anatomical insights into pain processing 2.1 Cerebrocortical and cerebellar contributions to pain modulation Pain is a multidimensional experience arising from the interplay of sensory, affective, cognitive, and social factors (20), processed through distributed brain networks that include the thalamus, brainstem nuclei, somatosensory cortices, and prefrontal regions (21)