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Among these, Asian countries (n = 4), European countries (n = 3), North American countries (n = 1), African countries (n = 1), and South American countries (n = 1) dominate the top 10 regions based on the total number of publications (Table 1)

Results indicate that the prevalence of intestinal barrier dysfunction is higher in patients with hypertension than in those without hypertension [45, 85,86,87,88]

In 1970, Orlowski and Meister proposed the -glutamyl cycle, which includes the synthesis, breakdown, export and import of GSH as a key process for amino acid uptake (Orlowski and Meister, 1970)

CYP1A2 displayed stable expression across Days 730, while CYP1B1 and CYP4F12 exhibited progressive increases, reaching maximum levels at Day 45, reflecting roles in fatty acid and bile acid metabolism during later stages