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This reparative effect is mediated, at least in part, through the upregulation and reorganization of key regulatory proteins, most notably protein kinase C (PKC) and the tight junction scaffolding protein zonula occludens-2 (ZO-2), thereby facilitating the reassembly and functional recovery of the tight junction complex (161)

Indeed, the first oncogene identified (SRC) was also the first Tyr kinase to be discovered 11,12 , and over 50 Tyr kinase inhibitorsincluding Gleevec, one of the earliest successful molecular medicinesare now FDA-approved cancer therapies 13,14

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