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5DF), and conversely, TUNEL-positive cells were decreased in this group (Fig

2019;18(1):e12876

With aging, there is a progressive loss of motor neurons, leading to muscle fiber denervation and fragmentation of the NMJ, which profoundly impairs efficient neurotransmission ( Mitochondrial dysfunction and oxidative stress, both prominent features of muscle aging and sarcopenia, have been shown to directly damage components of the NMJ (Sun et al., 2024)