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However, the representation of hot-spot mutants within the variant library was not particularly enriched in either the SKOV3 or OVCAR5 cell lines (Supplementary Fig

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Mdm2 and Mdmx Promote Ferroptosis by Pparalpha-Mediated Lipid Remodeling

As the disease progresses, damage to the antioxidant system, excessive OS, and altered Nrf2 expression levels, especially the inhibition of ferroptosis by lipid peroxidation inhibitors and adaptive enhancement of Nrf2 signaling, suggest that Nrf2 is essential for the detection and identification of ferroptosis and potential clinical implications of targeted therapy for neuronal loss and dysfunction