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Studies have shown that various gene mutations affecting the global regulation of AS or altering AS of specific genes are associated with human brain diseases ( Arabidopsis ( Arabidopsis under normal physiological conditions and various abiotic stress treatments revealed that isoforms generated by the AS play roles in responding to abiotic stress ( OsCYP19-4 gene produces various transcripts through AS, which have different subcellular localizations, and these isoforms play distinct roles in responding to cold stress ( With the advancement of AS research, it has become evident that genetic variations also play an integral role in regulating AS patterns

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