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Similarly, in vascular smooth muscle cells, luteolin blocks TGFBR1 signaling, suppressing Smad2/3 phosphorylation and inhibiting cell proliferation and migration

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337 Concurrently, age-related decreases in PINK1/Parkin-mediated mitophagy promote oxidative stress and mitochondrial dysfunction, which can trigger synovial inflammation and reduce the osteoclast activity critical for healthy bone remodeling, thereby contributing to joint damage and motor impairment

FIGURE 4 3.5 Immune evasion mechanisms DTP cells evade the recognition and elimination by the immune system via multiple means, presenting a significant and emerging challenge in treating AML, especially in the new era of immunotherapy against AML (91, 92)