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The general technical reproducibility of the normalised and logarithm-transformed data from the QC samples was good, with a mean coefficient of variation of ~3% over all the proteins

(PubMed) Kensler TW, Talalay P

Vitamin B12 plays a vital role in maintaining healthy nerve cells, supporting red blood cell production, and aiding in DNA synthesis

Moreover, conditional inactivation of IKK in mouse CNS and peripheral tissues impaired rhythmic activity behavior, thus revealing that IKK/NF-B pathway controls circadian behavioral and molecular rhythms in vivo to preserve circadian homeostasis 74