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SKU: 27466240793
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MedChemComm 1, 3038

The SigR-RsrA system of Streptomyces coelicolor and the Spx systems of Bacillus subtilis and Staphylococcus aureus have been most closely studied (Kang et al., 1999

46(5): 77584 Gaillard C, Van Cantfort J, Montay G, et al

However, the pleiotropic characteristic of cytokines and the widespread presence of cytokine receptors in various tissues lead to systemic toxicity if cytokines are delivered systemically, so in situ delivery of cytokines to tumors is necessary