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In the current study, we examined early changes in the levels of oxidative stress and the expression of major presynaptic [synapsin-I, synaptophysin, growth-associated protein-43 (GAP-43), synaptosomal-associated protein-25 (SNAP-25)] and postsynaptic [drebrin, synapse-associated protein-97 (SAP-97), and postsynaptic density protein-95 (PSD-95)] proteins in hippocampal synaptosomes from IP-STZ and ICV-STZ treated rats (two different models of imparted insulin signaling)

The UGT gene family drives this process, and variants can slow clearance enough to affect hormone balance, toxin clearance, and drug metabolism

Regorafenib (BAY 73-4506): a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity