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This heterogeneity reflected in the lack of synergy between our current diagnostic schema and our rapidly advancing scientific understanding of the condition puts a hard limit on all attempts to articulate an integrated perspective on bipolar disorder

N.Y.2010Acad

2.3 Astrocytes In the brain, astrocytes are glial cells and represent the most abundant non-neuronal cell type

167,336 Metabolic intermediates and by-products of the tricarboxylic acid cycle act as cofactors and substrates of various epigenetic enzymes, including acetyl CoA for acetylation and S-adenosylmethionine (SAM) for methylation