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Gastrointestinal side effects remain among the most common challenges during GLP-1 therapy, with diarrhea reported in clinical studies at rates between 20-25% depending on dose and medication type

Every Other Day (EOD) Dosing Every other day dosing at slightly higher per-session amounts (e.g., 23 mg EOD instead of 1 mg daily) is also used, particularly to reduce injection frequency or manage cost

Public docket FDA-2025-N-6895: Open for written comments through July 22, 2026, the day before the meeting convenes

Most available evidence comes from laboratory and animal studies, where researchers have observed potential effects on: Tendon healing Ligament repair Muscle recovery Gastrointestinal tissue repair Angiogenesis Inflammatory signaling Although these findings are promising, robust human clinical trials remain limited