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500 Cigarettes Meme: 'The Orville' Scene, Explained 500 CIGARETTES , The 500 cigarettes meme originates from a 2019 episode of the sci fi comedy series The Orville (Season 2, Episode 11: Lasting Impressions). In the scene, alien characters Bortus The 500 cigarettes meme comes straight from The Orville Season 2, Episode 11, when Bortus and Klyden discover human cigarettes from a time capsule and immediately spiral into fascination. What starts 500 cigarettes. The funniest and best delivered line in the series. Change my mind.

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