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Furthermore, we showed that rv 1127c is more susceptible to bedaquiline (BDQ) than wild-type (WT) Mtb (Mackenzie et al, 2020), and therefore drugs targeting Rv1127c may synergise with BDQ, which is the backbone of the oral, shortened treatments for antibiotic-resistant TB

Epub 2005 Jul 19

Seshadri S, Destefano AL, Au R, Massaro JM, Beiser AS, Kelly-hayes M, Kase CS, Dagostino RB, Decarli C, Atwood LD, Wolf PA (2007) Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham study

Despite roughly five decades of work, no DSIP-specific binding site has been cloned, no DSIP gene has been isolated, and no signal-transduction pathway downstream of DSIP binding has been definitively characterized