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Consent for publication All of the authors accepted last version of the article for publication and signed the authors disclosure

Huo S, Chen C, Lyu Z, Zhang S, Wang Y, Nie B, et al

Systemic approaches, including transcriptomic, chemogenomic and proteomics, have been employed to elucidate the anticancer mechanisms of ATO [56, 57]

In studies of human glioblastoma, the absence of exogenous Gln significantly reduces glutamate levels, resulting in the conversion of the dimer GLS1 into a self-assembled, extremely low Km filamentous polymer that further depletes intracellular Gln