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In the latter study, a significantly lower dose of human menopausal gonadotropin (HMG) was required in these women, which is expected given that women with PCOS typically have high serum anti-mullerian hormone (AMH) levels and are more prone to developing ovarian hyperstimulation syndrome (OHSS)

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CKD patients also exhibit a decreased relative abundance of Faecalibacterium [107]

This caution is not conservatism for its own sake: a systematic review and meta-analysis of laser therapy for melasma found that benefits are frequently offset by high recurrence and a real risk of rebound pigmentation, particularly in Fitzpatrick types IV to VI