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118 MaS.JiZ.ZhangB.GengL.CaiY.NieC.et al (2024)

Prevost et al., 2011), but there are few data for older youth

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Despite the high immunosuppressive efficacy, its adverse effects, narrow therapeutic window and high intra- and interpatient variability (IPV) in pharmacokinetics require therapeutic drug monitoring (TDM), which makes treatment with Tac a major challenge for physicians