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Then, what are its most important effects

Recently, it has been shown that IL-9 modulates IEB function, modifying TJs proteins expression

IL-10 is particularly important because it is one of the primary anti-inflammatory cytokines that Tregs use to suppress autoimmune responses

Therapeutically, neutralizing HMGB1 or blocking its receptor (RAGE/TLR4) has shown protection in preclinical sepsis and could be relevant in surgical SIRS as well