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J Physiol (1996) 495(Pt 2):46578

Exp Ther Med 12:611618 Refaie MMM, El-Hussieny M, Bayoumi AMA, Abdelraheem WM, Abdel-Hakeem EA, Shehata S (2024) Sacubitril/valsartan alleviates sepsis-induced myocardial injury in rats via dual angiotensin receptor-neprilysin inhibition and modulation of inflammasome/caspase 1/IL1 pathway

QIDSSR response was defined as a reduction from preinfusion score of 50% and remission was defined as a QIDSSR score 5

These inflammatory cytokines and chemokines then recruit more innate immune cells (monocytes, macrophages, neutrophils, DCs, and NK cells) and activate adaptive immune cells (CD4 + and CD8 + T cells) from the peripheral tissues to produce sustained inflammatory cytokines like IL-2, IFN-, and TNF-, which induce myelopoiesis and emergency granulopoiesis that further aggravate lung and epithelial damage (Fig