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It is supposed the homozygous genotype with the variant allele is rarer and less favourable for the subject (apart from specific exceptions) with respect to the homozygous wild type, bearing the commonest allele, while the heterozygous genotype is represented as an intermediate condition

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Sanches JM, Zhao LN, Salehi A, Wollheim CB, Kaldis P (2023) Pathophysiology of type 2 diabetes and the impact of altered metabolic interorgan crosstalk

Synapse-specific effects of IL-1 on long-term potentiation in the mouse hippocampus