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The EDSS is the most used scale for evaluating disability in MS patients

however, it should be noted that CK can also be elevated, particularly mildly elevated, in neurogenic processes and situations in which cramps are common (see also HyperCKemia in this issue)

Hence, we assessed the potential changes in the splicing pattern of brain genes associated with SMN deficiency from exon array analysis performed by [56], specifically focusing on those involved in the GABA synthesis and release pathway