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Sandoval ME (1980) Studies on the relationship between Ca2+ efflux from mitochondria and the release of amino acid neurotransmitters

Ann Transl Med 2021;9:732

A pivotal study using a STZ-induced diabetic rat model demonstrated that diabetes markedly reduces NRN1 expression in dorsal root ganglia and sciatic nerve, which are key anatomical structures affected in peripheral neuropathy (Karamoysoyli et al., 2008)