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Although they are promising anti-cataract drugs, these drugs have little effect on nuclear cataracts, suggesting multiple variables restrict their therapeutic effect (150,161), such as the lens nuclear barrier (150)

this is sensed by the retinoic acid-inducible gene-1 signaling, which is part of innate immunity receptors, leading to activation of -interferon, overexpression of MxA, and auto-amplification of perifascicular inflammation (126

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The thigh remains an excellent site for retatrutide, and the same rotation strategies apply