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NAD + consumption Sirtuins The discovery that NAD + acts as a cosubstrate for the sirtuin family of deacetylases and thereby effectively coordinates key metabolic processes, stress responses and ageing biology, heralded a new era of NAD + research at the very beginning of the twenty-first century [31,32,33]

Lipoxin A4 ameliorates knee osteoarthritis progression in rats by antagonizing ferroptosis through activation of the ESR2/LPAR3/Nrf2 axis in synovial fibroblast-like synoviocytes