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Females tend to be more magnesium deficient than males before age 50 (see Figure 6 )

On a therapeutic note, some microbiota-targeted treatments have reduced protein aggregates in models: long-term broad-spectrum antibiotics reduced A deposition and microglial reactivity in an AD mouse model, and recolonization with a simplified microbiota reversed some of these effects, indicating that specific microbial communities can either exacerbate or ameliorate protopathic cascades [102]

SeNPs overcome the narrow therapeutic window of aqueous Se, offering reduced systemic toxicity, demonstrated to be up to 10-fold lower in animal models, while maintaining or enhancing biological efficacy

Moreover, sour tea extract can suppress up to 50% of CYP-450 isoforms at doses between 306,000 and 1,660,000 mg/ml, meaning that caution should be exercised when sour tea is consumed alongside drugs (309)