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We refer readers to the FY 2013 IPPS/LTCH PPS proposed and final rules for additional background and a detailed description of this methodology (77 FR 28145 through 28146 and 77 FR 53700 through 53701, respectively)

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For example, one study of rectal absorption of the antibiotic latamoxef sodium in Witepsol H15, found that the addition of polysorbate 80 significantly increased release rate of the antibiotic and could significantly enhance both release rate of the suppository and membrane permeability of the rectum

of this Addendum, we are proposing to make changes in the determination of the prospective payment rates for Medicare inpatient operating costs for acute care hospitals for FY 2024