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A new generation of antidepressants: an update on the pharmaceutical pipeline for novel and rapid-acting therapeutics in mood disorders based on glutamate/GABA neurotransmitter systems

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Twenty subjects were randomized to receive the active cream and serum system (TPX) (Replenix Pure Hydration hyaluronic acid serum and Replenix Neckletage cream, Topix in West Babylon, New York), while 11 subjects were randomized to receive the vehicles alone in serum and cream format