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Cytosolic free mtDNA can act as a potential DAMP (Figure 2), as it is particularly sensitive to damage by ROS because it lacks histones for mtDNA protection and has no apparent mtDNA repair response (Yakes and Van Houten, 1997)

I completed my clinical training as a resident at Norwalk Hospital, Norwalk, Conn., and as a Fellow in Oncology and in Hematology at MD Anderson