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High levels of HEY2 recruit HDAC1 to the promoters of PGC-1 coactivator complex genes and carnitine palmitoyltransferase 1A/2 ( CPT1A/2 ) regulatory genes to mediate histone deacetylation and transcriptional repression, which results in decreased energy production, increased ROS levels, and cardiac dilation and failure

Together, these 65 scRNA-seq samples, newly reported here and from our two prior reports 11,26 , contained a total of 365,710 cell barcodes before quality control and filtering (Extended Data Fig

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