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MRI with gadolinium was conducted before the initiation of relacorilant and within 12 weeks after the last dose of relacorilant

Therefore, a better understanding of the molecular mechanisms underlying neurofibroma development, as well as the interaction of the tumor cells with the cells in the microenvironment will provide a foothold to develop new therapies aimed at delaying or preventing tumor formation in NF1 patients

95% CI, 1.61-1.71) compared to those with MASLD

This results in excessive excitatory drive, characterized by downregulation of GABA signaling and upregulation of postsynaptic N-methyl-D-aspartate (NMDA) receptors, which has been shown to manifest as anxiety-like behaviors that persist across generations (111) (Figure 11)