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FranceschiCBonafMValensinSOlivieriFDe LucaMOttavianiEet alInflamm-aging

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Dysregulation of internal environmental homeostasis and iron metabolism is closely related to the development of cardiac diseases, and iron overload is significantly detrimental to the development of ferroptosis and HF in cardiomyocytes (54)

Oxidative denaturation of hemoglobin leads to the release of hemin into the RBC membrane and the released hemin is capable of oxidizing membrane proteins via a thiyl radical intermediate