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They are formed in mitochondria as oxygen is reduced along the electron transport chain

Subsequently, 1 mg ml 1 (288 U ml 1 ) collagenase solution was added to give a final collagenase concentration of 5 U ml 1 (17 g ml 1 )

Paclitaxel-loaded solid lipid nanoparticles modified with Tyr-3-octreotide for enhanced anti-angiogenic and anti-glioma therapy

Importantly intracellular glutamate is a precursor of glutathione synthesis and, accordingly, HIF1-dependent intracellular glutamate accumulation can be used for glutathione biosynthesis, which can ultimately promote cell survival by counteracting oxidative stress (Stegen et al., 2016)