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Other methods for detecting mutations in biomarker genes include methods that use protection of the cleavage agent to detect mismatched bases in RNA/RNA or RNA/DNA heteroduplexes (Myers et al (1985) Science 230: 1242)

The low CSF-to-plasma ratio of compound D and the absence of compound Q in CSF may suggest the need for Phase Ib dosing studies to explore novel strategies for increasing Q bioavailability and D levels in the CNS

We reviewed relevant literature to screen natural products and their derivatives for the prevention and treatment of white hair based on melanosome transport and regulation (Fig