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FIGURE 1 PPI-induced digestive system complications FD FD is a digestive disease with numerous complex symptoms that lack obvious pathophysiological features

New insights into the pivotal role of the amygdala in inflammation-related depression and anxiety disorder

For example, integrin v 3 is highly expressed in the BBB, but its typical ligand, the RGD peptide, cannot effectively mediate BBB penetration for brain-targeted delivery

While Nrf2 and JAK2/STAT3 have protective roles, severe oxidative stress can also lead to their dysregulation or interaction with other pathways in ways that contribute to later-stage remodeling or inflammation (Mahdiani et al., 2022