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It selectively alkylates pyloric gland cells (46), leading to lesions primarily confined to the pyloric region (47, 48), potentially attributable to enhanced carcinogen accessibility to proliferative cells in the gastric antrum (49)

While the majority of the ALS cases (~9095%) are considered as sporadic (sALS) with unknown cause, ~510% cases involve Mendelian pattern of inheritance of familial gene mutations and are known as familial ALS (fALS) (Renton et al., 2014