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pre- and post-operative treatment, when requirements are increased as in fever, severe burns, increased metabolism, pregnancy, gastrointestinal disorders interfering with intake or absorption of vitamins, prolonged or wasting diseases, alcoholism and where other deficiencies exist

Combination protocols address two sequential bottlenecksfat mobilisation and fat oxidationthat single-agent therapies rarely optimise simultaneously, producing 2835% greater adipose reduction in research models

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No controlled human study has established a beneficial NAD effect or its clinical significance