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The relationship between gluten sensitivity and RA development has been further reinforced by two studies that demonstrated a reduction of antibody levels towards dietary antigens, promotion of anti-inflammatory effects, and protection against atherosclerosis in RA patients who adhered to a gluten-free, vegan-based diet (Hafstrm et al

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Upon binding to AREs in the nucleus, NRF2 interacts with other co-activators, such as the CBP/p300 protein, forming a complex that further activates the transcription of antioxidant and detoxification genes [30]